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We identified the 27K polypeptide to be the channel-forming domain by an in vitro permeability assay. Structure and function of the experimental polycystic kidney induced by diphenylthiazole with special reference to renal micropuncture study Clinical suspicion for a possible vena caval perforation by the catheter tip was confirmed by injection of contrast through the catheter.

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Delayed compliance increase in infants with respiratory distress syndrome following synthetic surfactant. Unique bioactivation of tiazofurin--studies with resistant cells. Histologically, we found a solid, undifferentiated tumor with clear signs of malignancy.

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Tertiary care institution, university-affiliated research laboratory. Our study revealed that age, stress level, marriage, occupation, asthma, atopic dermatitis, pulmonary tuberculosis, depression, thyroid disease, and parental AR history, all affected the prevalence of AR. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Synthesis, characterization and cytotoxicity of lanthanum(III) complexes with novel 1,10-phenanthroline-2,9-bis-alpha-amino acid conjugates. Simplicity and low cost has positioned inkjet paper- and fabric-based 3D substrates as two of the most commonly used surface-enhanced Raman spectroscopy (SERS) platforms for the detection and the identification of chemical and biological analytes down to the nanogram and femtogram levels.

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We have analyzed changes in the distribution and abundance of a mitogen-activated protein kinase kinase (MAPKK) enzyme (EC 2.7.1.37) known as ZmMEK1. We show that rabbit CCR5 promoter possesses features common to both humans and monkeys and lacks the second highly polymorphic region B in the CCR5 promoter that was previously identified in monkeys. This was a cross-sectional study with internal comparison of associated factors. The expression of the foreign Inhibitor I gene in leaves of each species was studied at the mRNA and protein levels.

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Interleukin-1 beta (IL-1 beta), IL-1 receptor antagonist, and TNF alpha production in whole blood. Patients tend to conceal their experience of visual hallucinations, but a discussion of these phenomena with the patient and assurance of their harmless nature will reduce his or her anxiety and concerns. We simulated changes in Latino smoking, morbidity, mortality, and quality-adjusted life years (QALYs) that would result from a range of actual and proposed cigarette excise-tax increases using a range of cigarette price-elasticity estimates specific to Latino smokers.

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Operative strategy should be based on routine frozen section of the surgical margin and perioperative endoscopic examination of the Wirsung duct with staged intraductal biopsies when technically feasible. Albinism is a heterogeneous group of conditions having in common a hereditary error of melanin metabolism resulting in misrouting of optic nerve fibers during embryogenesis, underdevelopment of the neuroretinas, and in varying degrees of hypopigmentation of eyes, skin, and hair. Growth of Mengo encephalitis virus in Ehrlich ascites cells in vitro. Deletion and dosage modulation of the eEF1A gene in Podospora anserina: effect on the life cycle. Anoxic coma after circulatory arrest: prospective study of intracranial pressure and cerebral perfusion pressure (apropos of 84 cases)

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SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. The staining pattern for parathyroid hormone ranged from negative or weak to strong, and from patchy to diffuse in hyperplastic tissue from different glands and within the same gland, regardless of the cell type. Conserved Noncoding Sequences Regulate lhx5 Expression in the Zebrafish Forebrain. SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors.

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Brucellosis is a well-known domestic animal infectious disease, which is caused by Brucella bacterium. There were statistically significant (P less than .001) t test differences between trough systolic and diastolic pressure and traditionally timed blood pressure readings.

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There was also a close relationship between increased oxidative metabolic formation of Me-DTC, high oxidative formation of acetaldehyde, and the full complements of a valid disulfiram ethanol reaction (DER). From June 1978 to June 1990, 48 patients (34 patients with skull base tumors and 14 with congenital hyperterolism) were treated by combined craniofacial surgery.

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Uterine length, procedure duration, and RFA index are associated with unfavorable outcomes and thus could be used to optimize postprocedure patient counseling. Management strategies to reduce the risks to human life and property from wildfire commonly involve burning native vegetation. Environments causing variation in age-specific mortality - ecological agents of selection - mediate the evolution of reproductive life-history traits. Hematological and immunohematological problems in this patient group are documented. Role of endoscopic ultrasonography in the loco-regional staging of patients with rectal cancer.

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In addition, it triggers osmotic diuresis, hypovolemia, and immunosuppression. D-sorbitol-induced phase control of TiO2 nanoparticles and its application for dye-sensitized solar cells.

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Results suggest that both therapist and client factors predict self-reported use of therapy techniques. Occlusive IVC thrombus was produced in 102 rabbits and treated 2 days later for 1 hour with pulse-spray thrombolysis using reteplase. Compared with operation, this method is easily performed and produces less damage and no significant sequelae, but the long-term effects have yet to be observed. D-amino acids are typically introduced to increase the peptide enzymatic stability.

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This report examines the factor structure of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) in a sample of 229 psychiatric patients from two community mental health centers (ages 16 to 85). A technique for the multiple transformation of yeast by protoplast fusion is described. This two-part report highlights a selection of important studies presented at this premier breast cancer event with part 1 focusing on radiotherapy treatment, translational approaches to immunotherapy and longer term cardiotoxicity from anti-HER2 therapies.

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Trials comparing cisplatin- and methotrexate-containing regimens with single-agent cisplatin or other cisplatin combinations have shown the apparent superiority of the former in terms of greater overall response rates and improved survival. The intron has been a big biological mystery since it was first discovered in several aspects.

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The use of chemotherapeutic agents in localized periodontal pockets. Future Directions: Additional value may be added to the experimental system described above by studying pigs with underlying health complications (e.g., metabolic syndrome), as is typically seen in patient populations. Adjuvant therapy is mainly understood as a hormonal treatment or polychemotherapy. Since heart beats are of a cyclical nature, compression can make use of the similarities in adjacent cycles by eliminating repetitive elements as redundant.

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Nuclear and cytoplasmic localization of a lectin-ribonucleoprotein complex. Intravenous nicorandil for treatment of the urgent phase acute heart failure syndromes: A randomized, controlled trial. These data suggest that tolmetin-HA treatment altered the levels of neutral protease activity secreted by postsurgical macrophages and may therefore elevate the fibrinolytic potential of the peritoneal cavity after surgery. The majority of CM efferents projecting to the thalamus were elongate cells, whereas the majority of CM efferents to the amygdala were round-oval cells.

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The results suggest that (R,S)-ketamine produces an immediate, concentration-dependent pharmacological effect on d-serine plasma concentrations. Inhibitors of protein biosynthesis and development of dyslipoproteinemia in rabbits The toxicity of fresh gasoline engine oils and that of fresh and used diesel engine oils are less well defined. Blood was also taken for enzyme linked immunosorbent assay (ELISA) (Helico-G) and latex agglutination (Pyloriset) tests.

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The question of biliary excretion of the hypolipidemic agent ciprofibrate (1) (2-(4-(2,2-dichlorocyclopropyl)-phenoxy)-2-methylpropionic acid H4 also induces aggregation, as assessed by confocal microscopy and light transmission assays. On the basis of chemical expansion, we further identified derivatives having increased activities toward Oct3/4 induction.

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Nucleotomy resulted in decreased disc pressure, decreased endplate deformation, and modified loading patterns onto the inferior vertebra in compression loading. The most striking feature of the brain pathology was the presence of large, abnormal astrocytes in the cerebellum, medulla, thalamus and in the dorsal horn of the spinal cord. The authors advocate percutaneous transpopliteal venography as a new method for evaluating the function of deep venous valves of the lower extremity. Ventricular volume and neurocognitive outcome after endoscopic third ventriculostomy: is shunting a better option? In rat PC12 pheochromocytoma cells, melittin, a phospholipase A2 activator, stimulated the release of arachidonic acid in a dose-dependent manner in the range between 0.1 and 1 microM.

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Tivantinib (ARQ 197) is an orally administered agent that targets MET, although recent preclinical data suggests the agent may have mechanisms of action that are independent of MET signaling. The bladder contractile response to substance P was similar in all groups of animals and vasoactive intestinal polypeptide was found to be devoid of contractile or relaxatory effects in the rat bladder. The system is solved using adaptive finite element methods in 3D axisymmetric geometries. However, this subcellular involution does not result in a change of the extent of the disease according to the American Fertility Society classification system. Ulcerative mucositis is a common, bothersome, and dose-limiting complication of cancer chemotherapy.

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A rare case of thrombocytopaenia induced by ethambutol is reported. BFA inhibited protein secretion in Vero cells but not in BFA-resistant cell lines, whereas EDIN did not inhibit protein secretion in either Vero or other cell lines.

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We present two cases of hypersensitivity to cefazolin (one anaphylaxis). The results indicate that serum concentration after oral administration is predictable by further analysis of therapeutic drug monitoring. We statistically analyzed the associations of these factors with disease-free survival (DFS). Haemopoietic regeneration of mice treated with fluorouracil was compared in samples obtained by flushing alone and grinding flushed femora.

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Atorvastatin (Lipitor) attenuates the effects of aspirin on pancreatic cancerogenesis and the chemotherapeutic efficacy of gemcitabine on pancreatic cancer by promoting M2 polarized tumor associated macrophages. In addition, CD59 inhibits the membrane attack complex (MAC) of the complement cascade. Our case is a first report showing reversibility of diffuse patchy pattern by a short-term treatment in severe PAH.

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The diagnosis could be confirmed by renal histology which showed occlusion of renal tubules by red blood cells and casts consistent with this diagnosis. Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. The public should be clearly told what care hospitals can and cannot provide and involved in decision-making.

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A protein of 38 kd was produced by the clone which reacted with the antibodies raised against the virus. Inhibition of ileal bile acid transporter: An emerging therapeutic strategy for chronic idiopathic constipation. Although total admissions peaked earlier during the year and showed a less consistent peak in October, there was a close resemblance between the periodicity of all diseases and that of peptic ulcer. Even though the studies published thus far are inconclusive or lack sufficient demonstration of efficacy to recommend a specific approach involving antimicrobial agents in routine clinical practice, several pieces of information from these studies suggest future avenues of investigation.

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This study is one of the first to document the trajectory of post-traumatic stress responses in parents of very ill children, across illness groups. DISPLACEMENT OF THE STOMACH AND A SEGMENT OF THE DUODENUM INTO THE POSTERIOR MEDIASTINUM THROUGH AN ESOPHAGEAL ORIFICE IN THE DIAPHRAGM Furthermore, we compare the accuracy of our open-source sweep-detection software OmegaPlus, which implements all four parallelization strategies presented here, with a variety of neutrality tests. Successful management of rheumatic conditions involves increasing complexity of care. We identified 2030 NSCLC patients at our institution from 1994 to 2014 and recorded their cigarette smoking status and history.

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The problem of neuritis with special consideration of intervertebral disk degeneration The latter methods may be particularly useful in clarifying a significant number of difficult diagnoses or in providing information on tumor location, to be combined with morphological observations regarding osteosarcomas. Decreasing the SL led to an increase in the FDL of about the same magnitude at all ages, and the same age differences were found at both SLs.

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This was not a false positive phenomenon since the positive ELISA reactivity of the heated SLE sera was markedly reduced by inhibition with the cardiolipin antigen. Exclusion criteria were the presence of an intracavitary thrombus, uncontrolled heart failure, moderate or severe valvular disease, and contraindications to general anaesthesia. Retrospective chart review of 104 consecutive patients diagnosed with head and neck NTM at a tertiary paediatric hospital between January 1994 and December 2013 inclusive. These findings support the development of a 15-item self-administered ADL Self-Care Scale. Some of these microbial components are noncultivable and vertically transmitted from generation to generation.

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NMR structure reveals intramolecular regulation mechanism for pheromone binding and release. The head of the metatarsal is then displaced laterally to provide correction of the hallux valgus.

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There was no difference either in the hatchability of the eggs or in larval size at hatch. They underwent endoscopic balloon dilatation and temporary stent (endoscopic retrograde biliary drainage tube) insertion. Identification of a noncatalytic domain in AMP deaminase that influences binding to myosin. Additionally, further research is required to explore the influence of receptive vocabulary on fast mapping capabilities. The effects of subchronic treatment with the antipsychotic drugs fluphenazine and sulpiride on the sensitivity of peripheral neuronal dopamine receptors and central dopamine autoreceptors were evaluated.

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We show a mutual stimulation in the endocytosis of debris and apolipoproteinJ (clusterin) in these cells. Maximum-parsimony, maximum likelihood and Bayesian analyses of molecular data from two nuclear DNA and six cpDNA regions support the monophyly of Petrocosmea and recover five major clades within the genus, which is strongly corroborated by the reconstruction of ancestral states for twelve new morphological characters directly observed from living material. These results strongly suggest that mycoplasmas possess an activity to induce TNF-alpha, which enhances the cytotoxic activity of macrophages and prevent infection with mycoplasmas in vivo. Subsequent treatment with piperidine selectively cleaved the DNA at specific modified bases in the sequence. Weanling male Sprague-Dawley rats were raised on egg protein diets containing 2.3 p.p.m.

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We sought to determine whether changes in allergen component-specific serum IgE and IgG4 levels during the updosing phase of subcutaneous immunotherapy (SCIT) are biomarkers of the immunologic changes that can lead to treatment efficacy. The ability of macrophages to stimulate immune responses is heterogeneous and may have influence on the type of the developing immune response. Long-chain and very-long-chain fatty acids are also metabolized by the cytochrome P-450 CYP4A omega-oxidation system to dicarboxylic acids that serve as substrates for peroxisomal beta-oxidation.

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In two patients with infantile myofibromatosis a coexpression of actin and desmin was found. The vigorous host response to the human gastric pathogen Helicobacter pylori fails to eradicate the organism, despite up-regulation of inducible NO synthase (iNOS) in the gastric mucosa. Antibiotic sensitivity patterns of Neisseria gonorrhoeae and prevalence of PPNG amongst local clinical isolates. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes.

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This paper explores the dominant issues in intergenerational ties in Arab countries with a view to highlighting patterns, trends and challenges as well as policy implications. Subsequently, the body becomes unable to compensate for an additional stress, and toxicity then develops. Effects of glutathione and of cysteine on intestinal absorption of selenium from selenite. Life quality of patients with benign tumors of the anterior and middle part of the skull base after surgery and during follow-up Review from US Army Institute of Surgical Research Fort Sam Houston San Antonio, Texas.

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To examine how well this process is evolutionarily conserved, we analysed the function of MLKL orthologues. Patients in the information condition were given the same sensation information about their specific preparation as those in choice. Characteristics of the immune system, hypophyseo-adrenal system and cyclic nucleotide balance in patients with lupus erythematosus

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This system may be a good tool to induce LAK cells for adoptive immunotherapy. Although several models of circRNA biogenesis have been proposed, the understanding of their origin is far from complete. Transglutaminases (Enzyme Commission 2.3.2.13) are a large family of enzymes that show the common capacity to catalyze cross-linking of protein substrates. Monocrotaline pyrrole alters DNA, RNA and protein synthesis in pulmonary artery endothelial cells.

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Levels of cord blood thyroid stimulating hormone and the incidence of false positive screening results for congenital hypothyroidism. mellificae was also detected in mason bees (Osmia bicornis and Osmia cornuta) besides in honey bees. We report on a case with the acquired form of the disease accompanied by leucocytoclastic vasculitis. These medications are often associated with adverse events and limited effectiveness in older adults.