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Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Remarkable perturbation of the DNA precursor metabolism, including release of precursor into the medium, was found to occur during citrinin treatment. The proposed framework demonstrated the feasibility of using 3D ultrasound imaging to estimate cardiac fiber orientation of in vivo beating hearts and its further improvements could contribute to understanding the dynamic mechanism of the beating heart and has the potential to help diagnosis and therapy of heart disease.

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MENINGOENCEPHALITIS DUE TO THE COXSACKIE VIRUS OF GROUP B TYPE 3 Electrocardiographic loading tests in persons with various ECG changes (findings of epidemiological studies)

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Although these lesions are recognized as separate and distinct pathological entities, a common pathogenesis is suggested by similarities in certain features. Other noxious agents about which there are still controversial opinions, are air pollution and occupational inhalants. CLINICAL APPLICATION OF A NEW VITAMIN B-12 DERIVATIVE (HYDROXOCOBALAMIN) WITH MASSIVE DOSES TO NERVOUS SYSTEM DISEASES

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In the control period, we found a significant phasic variation of pulmonary capillary pressure (Pc) with the cardiac cycle. vulnificus strains were found to be sensitive to nitrofurantoin (NT), ciprofloxacin (CIP), gentamicin (GN) and chloramphenicol (CO) and resistant to clindamycin (CI), penicillin (PN) and ampicillin (AP). Only a recent neuropsychological case study has provided initial evidence for the idea that these elements can be differentiated at a functional level. On the impulsivity dimension, bulimia nervosa patients scored in the high normal range, whereas bulimic anorexia nervosa patients rated in the low normal range.

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Capillary structure: its relation to psychiatric diagnosis and morphology. Spearman correlation coefficients close to 1.00 were noted in individual cases between the Periotest and the three other tests describing the percussion sounds.

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Motoneurons innervating the skeletal musculature were among the first neurons shown to require the presence of their target cells to develop appropriately. The effect of GEM on the expression of miR-218 in PANC-1 cells was also investigated. DISSIPATION OF PHENOTHIAZINE EFFECT AND RECURRENCE OF SCHIZOPHRENIC PSYCHOSIS. Influence of testosterone administration on the biosynthesis of unsaturated fatty acids in male and female rats.

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Clients with compensated bilharzial liver disease were chosen and were divided into three subgroups according to their own preference for the method of contraception. 15-Deoxy-delta(12,14)-prostaglandin J2 is a negative regulator of macrophage functions.

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Remnants of these predicted rearrangements have been brought out through fine analysis of the chromosome sequence. Hemosuccus pancreaticus due to a pressure ulcer in pancreatolithiasis Interaction frequency with acquaintances and close friends declined from early adulthood on. The disease itself is characterised by rigidity and degeneration of skeletal muscle, cataract formation, gonadal atrophy, frontal baldness and mental retardation. Soluble CEA(-related) antigens inhibited normal neutrophil adherence as well, whereas neutrophil transmigration was unaffected.

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It is concluded, therefore, that hyperactivity of corticostriatal neurons, rather than increased postsynaptic sensitivity to glutamate, accounts for the abnormal excitation of striatal neurons in the course of Mn intoxication. AIDS viruses require an intact functional nef gene in order to induce disease. Changes in the Golgi apparatus during hind limb regeneration in larval and metamorphic stages of Bufo regularis Reuss.

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The patient was discharged very much improved after these treatments, but she died of brain metastasis after 9 months. DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. It offers multiple advantages compared to other techniques such as a single-staged approach and the opportunity for reconstruction of a reliable wide bladder neck by usage of two well-vascularized flaps.

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Current approaches for the treatment of gingival exposure are often time- and cost-consuming and/or rather invasive. Behavior of back fat thickness, the activity of NADP-dependent dehydrogenases from adipose tissue and adipose tissue constituents fat and protein and their evidence for energy metabolism in dairy cows Joint Cross-Range Scaling and 3D Geometry Reconstruction of ISAR Targets Based on Factorization Method. Exposure to cytosine arabinoside alone induced beta- and epsilon-globin but not gamma-globin gene expression.

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Effects of puff number and puff spacing on carbon monoxide exposure from commercial brand cigarettes. Demand for maternal and child health (MCH) and PMTCT services can be limited by critical social, cultural, and structural barriers. We analysed differences between the populations of tyrosine phosphorylated proteins in two cell lines, K-562 and MR-87, which express two different bcr-abl fusion gene products, using both immunoprecipitation and Western blotting with an anti-phosphotyrosine antibody.

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We evaluated the effects of intravenous leptin (1 mg/kg over 3 hours) on arterial pressure and mesenteric, hindlimb, and renal blood flows in conscious rats. We asked 43 physicians with neonatal duties to perform two low compliance ventilation attempts and two normal-compliance ventilation attempts in a randomised order at baseline and after the educational intervention, with 34 taking part in a retest three months later. Mechanisms contributing to the development of vasospasm and abnormal reactivity of cerebral arteries after SAH have been intensively investigated in recent years. It may be offered as an alternative treatment to partial or radical nephrectomy under certain circumstances.

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RGDV and Ro 43-5054 induced conformational changes in purified inactive GPIIb-IIIa as determined by binding of the monoclonal antibody D3GP3 (D3). Diseases of the lymphatic vessels in children (lymphangioma, hemolymphangioma, lymphangitis) This study aims to examine patient profiles of transcranial Doppler (TCD) cerebral blood flow velocity (CBFv) and systemic blood pressure (BP) in subjects with and without papilledema at the time of surgery, and subsequent effect of cranial vault expansion.

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Prospective randomized comparison of rotational angiography with three-dimensional reconstruction and computed tomography merged with electro-anatomical mapping: a two center atrial fibrillation ablation study. Effect of amplitude of micromotion on bone ingrowth into titanium chambers implanted in the rabbit tibia. Rabbits were divided into heart failure positive control, adriamycin injection, and adriamycin injection with Wenyangzhenshuai treatment (low, medium and high dose) groups. Arginine-8-vasopressin (AVP, 6 micrograms/kg SC) administered 60 min prior to the experiment led to a prolonged behavioral and cardiac stress response in young and late-adult rats, but not in aged and senescent animals. The PPP-family protein phosphatases PrpA and PrpB of Salmonella enterica serovar Typhimurium possess distinct biochemical properties.

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Determination of glycohaemoglobin levels in ketonuric and non-ketonuric cows. Health promoting schools (HPS) is recognized globally as a multifaceted approach that can support health behaviours. Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study.

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Immunolocalization of beta 1 integrins in human gingival epithelium and cultured keratinocytes. Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons.

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To investigate vascular responses to the endothelin-1 (ET-1) precursor, human big endothelin 1-38 (big ET), in the peripheral vascular bed of the cat. Kluyver himself is poorly recognized today, yet his influence at the time was profound. On the harmful effect of fluorine in silicate cements on the dental pulp The heart was suspended in a glass chamber the oxygen partial pressure, PO2, of which could be varied.

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Association between Genetic Polymorphisms and Response to Anti-TNFs in Patients with Inflammatory Bowel Disease. A literature search yielded 175 articles discussing a total number of 516 cases, of which 147 articles discussed treatment in 276 individuals. High rates of physical and sexual abuse have been found among Alaska Native women entering a residential treatment program in Fairbanks, Alaska.

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From the urethral discharge we isolated Chlamydia trachomatis and, only during the attacks of cellulitis, Group G Streptococcus. Re: Is it reasonable to use 1 and 8 kHz anchor points in the medico-legal diagnosis and estimation of noise-induced hearing loss? An in vivo comparison of the step-back technique versus a step-back/ultrasonic technique in human mandibular molars. Methylome-wide association (MWAS) studies present a new way to advance the search for biological correlates for alcohol use. An Endovascular Approach for Ruptured Aneurysms of the Basilar Trunk Perforating Artery

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Effects pf multi-organ procurement on survival of the recipients and on renal graft survival In the hypertensive patients, flow-mediated dilatation was investigated and cyclic guanosine monophosphate plasma (cGMP) was measured before and at 8 weeks after the administration of 162 mg of aspirin. Ten pregnancies with a complete mole (i.e., hydropic placenta without a fetus), nine with stored serum samples and one with an AFP level only. After performing six sessions of hyperthermia treatment conducted at 42-45 degrees C for 30 min with 150 mg of CDDP and 180 mg of BLM, a subtotal oesophagectomy and lymph node dissection were performed. MS-based proteomics was applied to the analysis of the medicinal plant Artemisia annua, exploiting a recently published contig sequence database (Graham et al.

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However, in more complex situations relevant stimuli may not be set apart from other stimuli by a single defining property but by a specific combination of features. The mean interval from onset of symptoms to diagnosis is 14 months. Melanins are darkly pigmented polymers that protect organisms against environmental stress. A functional variant in the coding region of CAMTA2 is associated with left ventricular hypertrophy by affecting the activation of Nkx2.5-dependent transcription. In the leaky mterf6-1 mutant, a defect in photosynthesis is associated with reduced levels of photosystem subunits, although corresponding messenger RNA levels are unaffected, whereas translational capacity and maturation of chloroplast ribosomal RNAs (rRNAs) are perturbed in mterf6-1 mutants.

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Single-leaf partial meniscectomy in extensive horizontal tears of the discoid lateral meniscus: Does decreased peripheral meniscal thickness affect outcomes? They are influenced by advancing age and by alterations in mental function. OPTOMETRY practice acts: qualifications of applicants for examination. Emergency peritoneoscopy (laparoscopy) to evaluate a suspected intraabdominal catastrophe was performed in ten critically ill patients over a 3-year period. The extreme dependence on external oxygen supply observed in animals causes major clinical problems and several diseases are related to low oxygen tension in tissues.

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In rice, OsNCX1, OsNCX8, OsNCX9 and OsNCX15 were found to be highly expressed in all the plant parts and various developmental stages. A 59-year-old man presented with a case of SIH that manifested as a bilateral chronic SDH. External valve collapse is usually idiopathic and less likely to be associated with previous surgery. Multiple mutations, observed at a high frequency in the spontaneous and ultraviolet-induced mutation spectra following single-stranded DNA transfection, could be due to an error-prone polymerisation step acting on a single-stranded template. Structural alterations to the large arteries may, in hypertensive subjects, be responsible for an increase in the amplitude of pressure oscillation, leading to a disproportionate increase in systolic over diastolic blood pressure because of arterial (not arteriolar) changes.

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WETTABILITY OF POLY-(METHYL METHACRYLATE) TREATED WITH SILICON TETRACHLORIDE. Vincristine played a pivotal role in hematological remission of thrombotic thrombocytopenic purpura (T.T.P.) To evaluate the effectiveness and possible cost savings of influenza vaccination. Nurses, who form a vital part of the transfer team, cannot be expected to adapt easily to this form of advanced care without some form of training, which should be undertaken before individual nurses are allowed to perform this most important and responsible role.

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Assessment of myocardial viability with 201Tl SPET and reinjection technique: a quantitative approach. A prospective and comparative study of two matched groups was conducted. However, other measurements do not support the existence of magnetic order. Effects of the quantity of water and milk ingested concomitantly with AS-924, a novel ester-type cephem antibiotic, on its pharmacokinetics.

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Assessment of secreted apolipoprotein B showed that by incubating CaCo-2 cells with oleic acid, apolipoprotein B levels increased approximately 1.4-fold when compared to cells incubated with eicosapentaenoic acid, whereas the amount of triacylglycerol and size-range of particles were similar for the two fatty acids. From a mechanistic perspective, we hypothesize that OXT modulates interoceptive signals and self-referential processing, which may result in various social outcomes depending on context- and person-dependent variables such as early-life adversity. Existing methods are limited to correlation networks that are independently estimated from separate group-specific data and without due consideration of relationships that are conserved across multiple groups. In addition, VEGF expression was strongly correlated with PCNA expression and microvessel density. A new taxane diterpene and three known taxane diterpenes were isolated from the heartwood of Taxus mairei grown in Fujian province of China and identified as 1-dehydroxy-baccatin VI, baccatin VI, 1-dehydroxybaccatin IV, and taxinne J on the basis of spectral data.

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Using in situ hybridization, we show here that both IFI-54K and IFI-56K genes map to 10q23-q24. Type I is characterised by complete lack of intrahepatic portal venous blood flow due to an end to side fistula between main portal vein and the inferior vena cava.

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precarious living conditions, as evidenced by the indicators illiteracy, absence of prenatal care and poverty, were relevant for the risk of vertical HIV transmission, converging to the grouping of cases among disadvantaged regions. These results indicate the existence of cell-surface domains, specifically enriched in the above listed components, that may play a critical role in the so far poorly understood phenomenon of cell activation mediated through many different glycosyl-phosphatidylinositol-anchored (glyco)proteins and glycolipids. Thyrotrope-specific proteins play a critical role in TSH subunit gene expression, and influence T3-mediated regulatory mechanisms. Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage. High speed cinematographic analysis of subglottal mucosal vibration during experimentally induced phonation in excised larynges

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In contrast, mu4 binds equally well to the GTP- and GDP-bound forms of ARF1 and is less dependent on switch I and switch II residues. Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans.

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A patient referred for Mohs micrographic surgery of a basal cell carcinoma had a history of a congenital clotting factor IX deficiency requiring recombinant factor IX replacement. Nevertheless, a large amount of sCD4 remained cell-associated, presumably in the endoplasmic reticulum or an early golgi compartment, as indicated by the endo-beta-N-acetyl-D-glucosaminidase H (endo-H) sensitivity of its carbohydrate chains.

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When combining outcome data was not possible, we reported the results from individual studies. Measures of biosystem perturbation using a cybernetic approach based on stochastic models of photon emission processes are presented, and compared with classical measures. Their usefulness for the identification of biological traces is illustrated with casework examples. The radiotherapy of the breast or the chest wall is a complex technique. 8 of the 16 patients admitted to the trial were treated with kallikrein 100 K.U.

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The aim of this study was to compare the MPhi response, in terms of cytokine gene expression, to infection with the M. Moreover, aldosterone receptor antagonist therapy in diabetic and cardiopathic patients improved coronary flow. It appears as a natural strategy potentially suitable for the treatment of different kinds of pain.

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Drug liberation proceeded 15-17 times faster in cecum and colon homogenates than in aqueous pH 7.4 buffer or homogenates of the small intestine. Our data show that, during the first month of the combined treatment of sodium oxybate plus nalmefene, patients were able to achieve alcohol abstinence (two patients), to suppress (five cases) or reduce (two patients) episodes of heavy drinking days, and to suppress the onset of craving for sodium oxybate (one patient).

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A simple technique is presented for quick harvesting of cranial bone in patients who require limited amounts of bone to cover defects in the craniofacial area. When rates of key pecking were stable, a 5-s unsignaled, nonresetting delay to reinforcement separated the first peck after an interval elapsed from reinforcement in both components. This pattern of accessibility is consistent with beta(2)Val(93)-Leu(99) adopting a beta-strand conformation.

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The findings indicate that microsomes can be the site of receptor synthesis. Potential impact of primary health care reform on drug prescription in Spain: the Ciutat Badia experience The active compound was isolated by column chromatography on silica gel and identified as bakuchiol by means of spectral evidence. The evaluation of postoperative irradiation in patients with early-stage ovarian cancer.